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Sigma
Fibrinopeptide B human
F3379 -
≥97% (HPLC)
DOWNLOAD MSDS (PDF)CAS Number: 36204-23-6
Empirical Formula (Hill Notation): C66H93N19O25
Molecular Weight: 1552.56
MDL number: MFCD00076439
PubChem Substance ID: 24894841
Properties
| Related Categories | Blood, Clotting Factors, Coagulation Proteins and Reagents, Extracellular Matrix Peptides (ECM), Fibrinogen, |
| assay | ≥97% (HPLC) |
| storage temp. | −20°C |
| Gene Information | Research your gene in Your Favorite Gene powered by Ingenuity human ... FGB(2244) |
Description
Amino Acid Sequence
Glp-Gly-Val-Asn-Asp-Asn-G
Biochem/physiol Actions
Sequential release of fibrinopeptides by thrombin action on fibrinogen is essential to normal fibrin polymerization. Cleavage of fibrinopeptide B from fibrinogen Bβ chains exposes E domain polymerization sites, E(B), that interact with platelets, fibroblasts, and endothelial cells.
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Customers Also Viewed
50-70% protein (≥80% of protein is clottable)
Documents
Certificate of Analysis
Certificate of Origin
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Safety Information
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
Articles
Plasma Derived Proteins and Enzymes
Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Gas chromatography
References
Rooney, M.M., Mullin, J.L., Lord, S.T., Substitution of tyrosine for phenylalanine in fibrinopeptide A results in preferential thrombin cleavage of fibrinopeptide B from fibrinogen. Biochemistry 37, 13704-13709, (1998) Abstract
Mosesson, M.W., Fibrinogen and fibrin polymerization: appraisal of the binding events that accompany fibrin generation and fibrin clot assembly. Blood Coag. Fibrinolysis 8, 257-267, (1997)
Odrljin, T.M., Shainoff, J.R., Lawrence, S.O., Simpson-Haidaris, P.J., Thrombin cleavage enhances exposure of a heparin binding domain in the N-terminus of the fibrin beta chain. Blood 8, 2050-2061, (1996)
Vindigni, A., Di Cera, E., Release of fibrinopeptides by the slow and fast forms of thrombin. Biochemistry 35, 4417-4426, (1996) Abstract
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